Directed Biosynthesis of Unnatural Alkaloids in Dolichothele Sphaerica
نویسنده
چکیده
Using appropriate precursors, the two unnatural alkaloids 4(5)-[N-isocaproylaminomethyl]imidazole and 3-[2-N-isovalerylaminoethyl]pyrazole were produced by Dolichothele sphaerica. The former compound represents an unnatural alkaloid formed by the simultaneous introduction of two unnatural precursors, namely isocaproic acid and 4(5)-aminomethylimidazole. The latter compound represents an aberrant alkaloid formed by the introduction of a precursor of different heterocyclic entity, 3-aminoethylpyrazole.
منابع مشابه
DOLICHOTHELINE, A NOVEL IMIDAZOLE ALKALOID FROM DOLICHOTHELE SPHAERICA H. Rosenberg and A. G. Paul College of Pharmacy The University of Michigan
Alkaloids were extracted by the method previously reported and separated into phenolic and non-phenolic fractions (1). Crystallization of dolichotheline was accomplished by treating the condensed non-phenolic fraction with benzeneacetone (1:l). The crystalline base (0.02% on the basis of dry weight) melted at 130-131", was homogeneous on TLC and gave the characteristic red color of nonsubstitut...
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